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FOLFIRI
New research to combat diarrhea during chemotherapy
By Dross at 2007-02-22 03:29
 

 

 Diarrhea is a painful and dangerous side effect of chemotherapyterm treatments, sapping the energy, moisture and will to live from many patients. Researchers at MD Anderson cancer center have completed a phase I and animal trial (rat) of the use of celebrex, a COX-2 inhibitor, in combination with FOLFIRIterm chemotherapy. Initial results were positive, with 50% of the patients seeing an amelioration of their diarrhea. The researchers found a dose limiting toxicity of 200 mg/m2

 If you are suffering from the effects of diarrhea in your chemo treatments, do show your physician this story.

read more | 2 comments | 4827 reads

Colorectal Cancer Basics
By HCat at 2007-01-16 12:35

Colorectal Cancer Basics

 

Hereditary CRC

Colorectal cancer (CRC) can be divided into two basic types, hereditary or sporadic.

    Hereditary CRC are germlineterm (passed to offspring) mutations (a damaging change in DNA) with two well described forms. These hereditary mutations are thought to reduce the time it takes for the cells to turn cancerous. Mutations can be thought of in terms of “hits”. One hit is one mutation. It is thought that a normal cell needs 3 to 6 hits to become cancerous. With an inherited mutation, there is one fewer hit needed to reach the correct number to transform the cell to cancer. One odd aspect to CRC is that there is a relatively well defined set of events for the progression from adenomaterm to carcinomaterm.

read more | 29295 reads

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