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CEA
Phase II Clinical Trial of Cytogens QUADRAMET with PSA-TRICOM Initiated for Hormone-Refractory Prostate Cancer Patients
By HCat at 2007-03-06 10:40
 

    At the beginning of March with the sponsorship of the National Cancer Institute (NCI), Cytogen Corporation it has initiated a randomized Phase II study to evaluate QUADRAMET (samarium Sm-153 lexidronam injection) in combination with PSA-TRICOM from the National Institute of Health (NIH). The patient base is for those who have failed docetaxel-based regimens.

    The study will determine if QUADRAMET alone or in combination with PSA-TRICOM can improve 4-month progression-free survival (PFS). There is currently no protocol for treatment of hormone-refractory patients who have advanced on docetaxel regimens.

    In April 2006, NCI researchers presented results of a preclinical study at the 97th Annual Meeting of the American Association for Cancer Research. The study, "Use of Samarium-153 (QUADRAMET) to modulate phenotype and enhance killing of tumor cells" demonstrated that exposure to QUADRAMET resulted in up-regulation of surface molecules on cancer cells, including Fas (CD95), carcinoembryonic antigen (CEA), mucin 1 (MUC-1), intercellular adhesion molecule-1 (ICAM-1 or CD54), and major histocompatibility complex class I (MHC-1). Each of the five molecules evaluated in the study has been implicated in enhancing anti-tumor T-cell responses through diverse mechanisms.

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Colorectal Cancer Basics
By HCat at 2007-01-16 12:35

Colorectal Cancer Basics

 

Hereditary CRC

Colorectal cancer (CRC) can be divided into two basic types, hereditary or sporadic.

    Hereditary CRC are germlineterm (passed to offspring) mutations (a damaging change in DNA) with two well described forms. These hereditary mutations are thought to reduce the time it takes for the cells to turn cancerous. Mutations can be thought of in terms of “hits”. One hit is one mutation. It is thought that a normal cell needs 3 to 6 hits to become cancerous. With an inherited mutation, there is one fewer hit needed to reach the correct number to transform the cell to cancer. One odd aspect to CRC is that there is a relatively well defined set of events for the progression from adenomaterm to carcinomaterm.

read more | 29295 reads

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