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hormone refractory
Phase II Clinical Trial of Cytogens QUADRAMET with PSA-TRICOM Initiated for Hormone-Refractory Prostate Cancer Patients
By HCat at 2007-03-06 10:40
 

    At the beginning of March with the sponsorship of the National Cancer Institute (NCI), Cytogen Corporation it has initiated a randomized Phase II study to evaluate QUADRAMET (samarium Sm-153 lexidronam injection) in combination with PSA-TRICOM from the National Institute of Health (NIH). The patient base is for those who have failed docetaxel-based regimens.

    The study will determine if QUADRAMET alone or in combination with PSA-TRICOM can improve 4-month progression-free survival (PFS). There is currently no protocol for treatment of hormone-refractory patients who have advanced on docetaxel regimens.

    In April 2006, NCI researchers presented results of a preclinical study at the 97th Annual Meeting of the American Association for Cancer Research. The study, "Use of Samarium-153 (QUADRAMET) to modulate phenotype and enhance killing of tumor cells" demonstrated that exposure to QUADRAMET resulted in up-regulation of surface molecules on cancer cells, including Fas (CD95), carcinoembryonic antigen (CEA), mucin 1 (MUC-1), intercellular adhesion molecule-1 (ICAM-1 or CD54), and major histocompatibility complex class I (MHC-1). Each of the five molecules evaluated in the study has been implicated in enhancing anti-tumor T-cell responses through diverse mechanisms.

read more | 5189 reads

Prostate Cancer Basics
By HCat at 2007-01-07 02:11

The Androgen Receptor

   The Androgen Receptor (AR) is a protein inside of certain cells that can bind or capture the androgen hormones testosterone and the more active metabolite 5alpha-dihydrotestosterone (DHT). Once the receptor binds one of the hormones, it causes the receptor to become active and stimulate production of certain proteins inside cells such as PSA.

It is known that AR is required for the normal development of the prostate. If a male animal has no AR, then the prostate will not be created of will be very small when he is born.

read more | 25711 reads

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