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Breast Cancer
1-step breast cancer treatment combines radiation, surgery
By Dross at 2007-06-20 04:25

(Toronto – June 19, 2007) – Princess Margaret Hospital (PMH) breast cancer specialists are using a new way to treat patients by delivering a one-time dose of radiation during surgery. The procedure, called intraoperative radiation therapy, takes less than an hour and eliminates the need for further radiation treatments.

On May 17, the PMH team combined the expertise of surgeons, radiation medicine specialists (radiation oncologists, physicists and therapists) and nurses to perform its first procedure. It marked the first time the portable intrabeam radiotherapy machine that makes this procedure possible has been used in Canada. The PMH team has since treated two more patients.

read more | 665 reads

Penn: Office of University Communications: Fluorescence Diffuse Optical Tomography Provides High Contrast, 3-D Look at Breast Ca
By Dross at 2007-06-13 23:56

Researchers at the University of Pennsylvania have created the first three-dimensional optical images of human breast cancer in patients based on tissue fluorescence.

Fluorescence diffuse optical tomography, or FDOT, relies on the presence of fluorophore molecules in tissue that re-radiate fluorescent light after illumination by excitation light of a different color.  The reconstructed images demonstrated significant tumor contrast compared to typical endogenous optical contrast in breast.

Tumor-to-normal tissue contrast based on FDOT with the fluorophore Indocyanine Green, or ICG, was two-to-four-fold higher than contrast based on endogenous contrasts such as hemoglobin and scattering parameters obtained with traditional diffuse optical tomography, or DOT.

read more | 806 reads

Study suggests newer breast cancer drug may protect heart
By Dross at 2007-06-10 02:49

DURHAM, N.C. -- By uncovering how one breast cancer drug protects the heart and another does not, Duke University Medical Center researchers believe they may have opened up a new way to screen drugs for possible heart-related side effectsterm and to develop new drugs.

The Duke researches compared the actions of two breast cancer drugs in experiments involving human cells and rats. The drugs in question were the older drug trastuzumab, whose trade name is Herceptin, and the newer drug lapatinib, whose trade name is Tykerbterm.

The results of the study appear early online in the journal Proceedings of the National Academy of Science.

read more | 1365 reads

Diet and exercise key to surviving breast cancer, regardless of obesity, new UCSD study says
By Dross at 2007-06-10 02:49

Breast cancer survivors who eat a healthy diet and exercise moderately can reduce their risk of dying from breast cancer by half, regardless of their weight, suggests a new longitudinal study from the Moores Cancer Center at the University of California, San Diego (UCSD).

Previous studies have looked at the impact of diet or physical activity on breast cancer survival, with mixed results. This study, published in the June 10 issue of the Journal of Clinical Oncology, is the first to look at a combination of both in breast cancer.

“We demonstrate in this study of breast cancer survivors that even if a woman is overweight, if she eats at least five servings of vegetables and fruits a day and walks briskly for 30 minutes, six days a week, her risk of death from her disease goes down by 50 percent,” said the paper’s first author, John Pierce, Ph.D., director of the Cancer Prevention and Control Program at the Moores UCSD Cancer Center. “The key is that you must do both.”

read more | 941 reads

Increasing radiation dose shortens treatment time for women who choose breast sparing treatment
By Dross at 2007-05-31 22:29

Radiation therapy after lumpectomy for early-stage breast cancer can be safely delivered in higher daily doses to greatly reduce treatment time. This conclusion of a new Fox Chase Cancer Center study is good news for women who might opt to have a mastectomy instead of a lumpectomy because of the time commitment needed for the usual six-week radiation course with the breast-sparing surgical option.

The curative outcome for early-stage breast cancer is the same whether a woman chooses to have a lumpectomy or mastectomy, the removal of the entire breast. Many factors influence a woman's decision when considering the two options. One of these factors is the time commitment for the recommended radiation course that follows a lumpectomy. Radiation significantly reduces the chance that cancer will recur in the affected breast, but the usual time commitment—five days a week for six or seven weeks—can be a barrier for choosing this treatment option.

read more | 1 comment | 1234 reads

Excercise levels and Breast Cancer Outcome
By Dross at 2007-05-21 21:35

Women diagnosed with breast cancer should either get exercising or keep exercising. This is the message from a new study in Springer%u2019s Journal of Cancer Survivorship by Catherine Alfano and colleagues at the Ohio State University1. The study of over 500 women who had survived breast cancer highlights how physical activity, and more specifically the intensity and amount of physical activity you do before and after cancer treatment, can affect future symptoms and your quality of life. Cancer symptoms and those brought on by its treatment can have a huge impact on everyday life. Physical symptoms commonly include fatigue, post-surgery pain, hormone-related symptoms in-cluding hot flashes, sweats, palpitations, urinary incontinence and cognitive and mood changes. Psychological effects such as anxiety and depression are also common. Physical symptoms exacerbate anxiety as they are a constant reminder of the cancer and add to the worry about whether it will recur. Some of these symptoms are seen in cancer survivors as long as 20 years after the cancer has gone.

read more | 765 reads

Chemotherapy more effective when given before breast cancer surgery
By Dross at 2007-05-14 21:49

Giving chemotherapyterm to women with operable breast cancer before they have surgery —not after — helps physicians pin down the best treatment regimen and can reduce the extent of surgery, according to a new systematic review.

Preoperative chemotherapy reduced chemo-related infections by 4 percent and the need for mastectomies by 17 percent when compared to postoperative chemotherapy, found reviewers led by Sven Mieog, M.D., of Leiden University Medical Center in the Netherlands.

Mieog and colleagues looked at 14 studies that included 5,500 women with operable breast cancer. Half of the women received preoperative chemotherapy and the rest received chemotherapy after surgery.

read more | 1 comment | 1774 reads

What's in the water? Estrogenic activity documented in fish caught in Pittsburgh's rivers
By Dross at 2007-04-17 23:19

LOS ANGELES, April 17 – A new study from the University of Pittsburgh Cancer Institute's Center for Environmental Oncology suggests that fish caught in Pittsburgh rivers contain substances that mimic the actions of estrogen, the female hormone. Since fish are sentinels of the environment, and can concentrate chemicals from their habitat within their bodies, these results suggest that feminizing chemicals may be making their way into the region's waterways.

The study, abstract number 3458, being presented at the annual meeting of the American Association for Cancer Research, April 14-18, at the Los Angeles Convention Center, also demonstrated that the chemicals extracted from the local fish can cause growth of estrogen-sensitive breast cancer cells cultured in the laboratory. Extracts of fish caught in areas heavily polluted by industrial and municipal wastes resulted in the greatest amount of cell growth.

read more | 1290 reads

Breast cancer diagnosis from combined MRI-optics method
By Dross at 2007-04-13 23:39

By combining two techniques, magnetic resonance imaging (MRI) and near-infrared optics, researchers at Dartmouth College and Dartmouth Medical School may have devised a new, potentially more accurate method for diagnosing breast cancer. Their pilot study, demonstrating the feasibility of the concept, is published in the April 15 issue of the journal Optics Letters, published by the Optical Society of America.

The new technique utilizes MRI to produce an image of the breast, yielding information on its structure, including shape and composition. The near-infrared light technique provides information on how the tissue is functioning, for example, whether a region contains a large amount of blood and is rapidly consuming oxygen as early cancers typically do. The researchers are hoping this dual-procedure approach will be a key to learning which tissues are malignant before performing a biopsy.

read more | 681 reads

MRI and Contralateral Breast Cancer
By Dross at 2007-03-28 22:39

Up to 10 percent of women newly diagnosed with cancer in one breast develop cancer in the opposite breast. Results of a major clinical trial show that magnetic resonance imaging (MRI) scans are highly effective tools for quickly identifying these opposite breast cancers, detecting diseased tissue that other screening methods missed.

In the new trial, conducted by the American College of Radiology Imaging Network (ACRIN) and funded by the National Cancer Institute, researchers wanted to determine whether MRI could improve doctors’ ability to identify these opposite breast cancers right at the initial diagnosis – boosting the chances for swift and successful treatment.

read more | 1704 reads

AGD - New Saliva Test May Help Dentists Test for Breast Cancer
By Dross at 2007-03-22 03:20

Breast cancer is the second leading cause of death among women in the United States.  In 2006, the American Cancer Society estimated that there would be 212,920 new cases of invasive breast cancer, and in that year, 40,970 women would die from it.  Many women’s lives could be saved if this cancer was diagnosed earlier, and early diagnosis could be achieved if there were more and easier opportunities to do so.

Sebastian Z. Paige and Charles F. Streckfus, DDS, MA, the authors of the study, “Salivary analysis in the diagnosis and treatment of breast cancer,” published in the March/April 2007 issue of General Dentistry, the Academy of General Dentistry’s (AGD) clinical, peer-reviewed journal, researched a new method of diagnosis.

read more | 1093 reads

Chemosensitive p53-mutant breast cancers
By Dross at 2007-03-20 20:44

Hugues de The and colleagues report that TP53 status is a predictive factor for responsiveness in breast cancers to a dose-dense epirubicin-cyclophosphamide chemotherapyterm regimen, and suggests that this regimen might be well suited for patients with TP53 mutant tumors.


[via Chemosensitive p53-mutant breast cancers]:

669 reads

UBC discovery may lead to 'smart' therapies for breast, ovarian cancer
By Dross at 2007-03-19 19:40

New non-toxic and targeted therapies for metastaticterm breast and ovarian cancers may now be possible, thanks to a discovery by a team of researchers at the University of British Columbia.

In a collaboration between UBC stem cell and cancer scientists, it was found that a protein called podocalyxin – which the researchers had previously shown to be a predictor of metastatic breast cancer – changes the shape and adhesive quality of tumour cells, affecting their ability to grow and metastasize. Metastatic cancer is invasive cancer that spreads from the original site to other sites in the body.

read more | 1639 reads

Racial disparities seen in male breast cancer survival
By Dross at 2007-03-18 03:49

A single surgery to remove cancer from both the colon and the liver to which it has spread may be better in some cases than the current standard treatment of two separate surgeries with chemotherapyterm in between, according to a study led by Duke University Medical Center researchers.

Simultaneous surgeries on the colon and liver may reduce the length of a patient’s stay in the hospital and potentially lessen the risk of surgical complications without compromising long-term survival, according to the study.

"In about a third of patients who are newly diagnosed with colorectal cancer, the cancer has already spread to the liver," said Bryan Clary, M.D., a surgical oncologist at Duke and senior investigator on the study. "The standard approach for these patients has been to remove the colorectal cancer and give them chemotherapy afterwards, waiting to remove liver tumors later if patients do not appear to be developing disease elsewhere in the body. These findings suggest there might be an alternative that is as safe and may even lead to better outcomes."

read more | 1286 reads

PF-3512676 (CPG 7909) Non-Small-Cell-Lung Immuno-modulatory Treatment Development History
By HCat at 2007-03-17 07:11

    Coley Phamaceutical Group has developed oligonucleotides which contain CpG motifs (the nucleotides cytosine and guanine in repetition) that help immune responses. The oligonucleotides illicit an immune response by affecting toll-like receptor (TLR) function, with the main one being TLR9. Here is a link to a basic picture of TLR function in the immune response from the company website. The CpG motifs in bacterial DNA have been shown years ago to illicit an immune response. Here is a link to an abstract of a paper on induction of an immune response by CpG motifs from bacterial DNA.

read more | 9008 reads

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