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Immune system to fight brain tumors
By Dross at 2013-05-31 00:35
 

Research at Lund University in Sweden gives hope that one of the most serious types of brain tumour, glioblastoma multiforme, could be fought by the patients' own immune system. The tumours are difficult to remove with surgery because the tumour cells grow into the surrounding healthy brain tissue. A patient with the disease therefore does not usually survive much longer than a year after the discovery of the tumour. The team has tested different ways of stimulating the immune system, suppressed by the tumour, with a 'vaccine'.

 

read more | 7 comments | 2945 reads

Sweeping Study Of Cancer Metabolism Identifies Hundreds Of Alterations And Potential Drug Targets To Starve Tumors
By gdpawel at 2013-05-02 14:06
 
 
A massive study analyzing gene expression data from 22 tumor types has identified multiple metabolic expression changes associated with cancer. The analysis, conducted by researchers at Columbia University Medical Center, also identified hundreds of potential drug targets that could cut off a tumor's fuel supply or interfere with its ability to synthesize essential building blocks.

read more | 2 comments | 3299 reads

Leading leukemia experts: High leukemia treatment costs may be harming patients
By Dross at 2013-04-26 00:29
 

 The increasing cost of treatments for chronic myeloid leukemiaterm (CML) in the United States has reached unsustainably high levels and may be leaving many patients under- or untreated because they cannot afford care, according to a Blood Forum article supported by nearly 120 CML experts from more than 15 countries on five continents and pu

read more | 3009 reads

Researchers Identify New Pathway, Enhancing Tamoxifen to Tame Aggressive Breast Cancer
By Dross at 2013-04-24 23:48
 

Tamoxifen is a time-honored breast cancer drug used to treat millions of women with early-stage and less-aggressive disease, and now a University of Rochester Medical Center team has shown how to exploit tamoxifen’s secondary activities so that it

read more | 1 comment | 3032 reads

Virus kills melanoma in animal model, spares normal cells
By admin at 2013-04-24 22:56
 

Researchers from Yale University School of Medicine have demonstrated that vesicular stomatitis virus (VSV) is highly competent at finding, infecting, and killing human melanoma cells, both in vitro and in animal models, while having little propensity to infect non-cancerous cells.



"If it works as well in humans, this could confer a substantial benefit on patients afflicted with this deadly disease," says Anthony van den Pol, a researcher on the study. The research was published online ahead of print in the Journal of Virology.

read more | 2341 reads

Screening breast ultrasound detects cancers missed on mammography in women with dense breasts
By Dross at 2013-04-18 22:02
 

Screening breast ultrasound performed after mammography on women with greater than 50% breast density detects an additional 3.4 cancers or high risk lesions per one thousand woman screened, a detection rate just under that of screening mammography alone for women with less dense breasts, a new study shows. Screening mammography detects 4-5 cancers per thousand women screened.

read more | 1 comment | 2365 reads

New ablation technique holds promise for liver cancer patients
By Dross at 2013-04-18 21:55
 

A new minimally invasive tumor ablation technique is providing hope for liver cancer patients who can't undergo surgery or thermal ablation, a study shows.

The study of 22 patients at the Universitatsklinikum Regensberg in Regensberg, Germany, found that irreversible electroporation (IRE) successfully destroyed tumor tissue in 70% of these patients.

read more | 2 comments | 2463 reads

CT and serum LDH shows promise as survival predictor for some metastatic melanoma patients
By Dross at 2013-04-17 18:05
 

Combining CT imaging findings with baseline serum lactate dehydrogenase levels is showing promise as a way to predict survival in patients with metastaticterm melanoma being treated with anti-angiogenic therapy.

read more | 2642 reads

Circadian Rhythm and the Myc oncogene.
By Dross at 2013-04-10 07:49
 

The Myc oncogene can disrupt the 24-hour internal rhythm in cancer cells. Postdoctoral fellow Brian Altman, PhD, and graduate student Annie Hsieh, MD, both from the in the lab of Chi Van Dang, MD, PhD, director of the Abramson Cancer Center, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, present their data in the "Metabolic Pathway Regulation in Cancer" session at the 2013 American Association for Cancer Research meeting, Washington, D.C., April 9, 2013.

read more | 3 comments | 1500 reads

Brighton researchers' discovery may prolong cancer patients’ lives
By gdpawel at 2013-03-20 08:57
 

Cancer patients around the world could have their lives extended thanks to a discovery made by Sussex scientists.

Researchers at the University of Sussex, who have been working with the Institute of Cancer Research, have found that a cutting-edge cancer drug may be able to keep patients alive for longer than they live now.

The discovery by the researchers, who looked at exactly how the drugs attack tumours, has been hailed as “unexpected and exciting”.

The drugs, known as kinase inhibitors, are a new type of treatment, with 25 currently in use on a variety of cancers.

read more | 5 comments | 1753 reads

For Smokers, Low Levels of Vitamin D May Lead to Cancer
By Dross at 2013-03-16 05:26
 

New research appearing online today in Clinical Chemistry, the journal of AACC, shows that decreased levels of vitamin D may predispose smokers to developing tobacco-related cancer. This study illustrates that simple vitamin D blood tests and supplements have the potential to improve smokers' health.  In the U.S. alone, cigarette smoking accounts for more deaths annually than HIV, illegal drugs, alcohol, motor vehicle injuries, suicides, and murders combined.

read more | 1 comment | 1510 reads

Small molecules in the blood might gauge radiation effects after exposure
By Dross at 2013-02-26 23:50
 

Currently, doctors have no way to accurately measure damage to the body soon after a person is exposed to ionizing radiation.
It is therefore difficult to know whether a person is likely to suffer serious effects after an occupational or accidental exposure.
This animal study shows that radiation exposure alters the levels of certain small molecules in the blood, perhaps offering a reliable measure of damage to the body.

read more | 2 comments | 1747 reads

Molecular master switch for pancreatic cancer identified, potential predictor of treatment outcome
By Dross at 2013-02-13 23:38
 

PHILADELPHIA – A recently described master regulator protein may explain the development of aberrant cell growth in the pancreas spurred by inflammation

A team from the Perelman School of Medicine at the University of Pennsylvania profiled gene expression of mouse pancreatic ductal and duct-like cells from different states - embryonic development, acute pancreatitis and K-ras mutation-driven carcinogenesis - to find the molecular regulation of these processes.

read more | 3 comments | 1691 reads

Emerging cancer drugs may drive bone tumors
By Dross at 2013-02-13 23:32
 

Cancer drugs should kill tumors, not encourage their spread. But new evidence suggests that an otherwise promising class of drugs may actually increase the risk of tumors spreading to bone, according to researchers at Washington University School of Medicine in St. Louis.

The drugs, IAP antagonists, block survival signals that many cancer cells rely on to stay alive. Working in mice, the investigators found that targeting the same protein that makes tumors vulnerable to death also overactivates cells called osteoclasts, which are responsible for tearing down bone.

read more | 2 comments | 1736 reads

Chemotherapy Recommendations Based on Published Reports of Clinical Trials
By gdpawel at 2013-01-28 10:47
 

The American Society of Clinical Oncologists (ASCO) says oncologists should make chemotherapy treatment recommendations on the basis of published reports of clinical trials and a patient’s health status and treatment preferences.

How about published reports of clinical trials?

More chemotherapy is given for breast cancer than for any other form of cancer and there have been more published reports of clinical trials for breast cancer than for any other form of cancer.

read more | 5 comments | 2057 reads

 
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